Tox Boxes are enemies that appear in Super Mario 64, Super Mario 64 DS and Super Mario Galaxy. They earned their name from a pun on "Toy Box" and "Toxin". They appear to be based off the "oni", a Japanese daemon that blocks your route.
Tox Boxes appear as large metal boxes with faces spray-painted on 5 sides in Super Mario 64 and its sequel, while their bottom has an opening that the player can hide in to avoid them. In Super Mario 64 DS, only Wario can destroy Tox Boxes by jumping while inside their interior. In Super Mario Galaxy and Super Mario Galaxy 2, they appear to be stone-carved, rather to be spray-on, and the opening is colored red to resemble a mouth.
In every platformer game they appear in, Tox Boxes roll on a set path. They never deviate from their route, and they will instantly kill anyone they crush, but they can be avoided. Variants called Fast Tox Boxes appear in the Beach Bowl Galaxy of Super Mario Galaxy and Stone Cyclone Galaxy in Super Mario Galaxy 2. They also have a relative called a Grumblump that appears in Super Mario 3D World, in the stage Grumblump Inferno
Tox Boxes make their final appearance in Mario Party: Island Tour. The only minigame to feature them is Tox Box Shocks, where the player must hide from the rampaging Tox Boxes. As the game progresses, their speed increases. Unlike the platformers, they have no predetermined route and follow path of their choice.