Hotel Delfino is a hotel located at Sirena Beach on Isle Delfino. It is directly sourced from the real life Hotel Delfino. The exterior with the beach and pools strongly resembles (and may even be based on) the front area of a popular resort in Cancun, Mexico. It should be noted that most of the episodes of Sirena Beach takes place in Hotel Delfino.
Once after Mario completes the first episode of Sirena Beach, Hotel Defino will become accessible to enter. During the second episode, the Hotel Owner will ask Mario to help with the ghost problem and Mario enters where he finds several Boos flying around. Once the third episode is reached, Mario can now enter the casino area. This is also where Mario fights King Boo in the game. Mario can also fight Shadow Mario throughout the Hotel while avoiding fake Shadow Mario's that are Boos in disguise.
- 303: Sorage Room/Dolpic Poster Room
- 304: Timid Noki Girl Suite
- 306: Changing room
|Characters||Protagonists||Mario • F.L.U.D.D. • Princess Peach • Toadsworth|
|Antagonists||Bowser • Bowser Jr./Shadow Mario|
|Other Characters||Il Piantissimo • Pianta • Noki • Noki Elder • Noki Elder's Grandson • Toad • Hotel Delfino Manager • Yoshis|
|Locations||Areas||Isle Delfino • Delfino Airstrip • Delfino Plaza • Bianco Hills • Ricco Harbor • Gelato Beach • Pinna Park • Sirena Beach • Noki Bay • Pianta Village • Corona Mountain|
|Other Areas||Windmill Village • Hotel Delfino|
|Bosses||Main Bosses||Bowser • Bowser Jr. • Shadow Mario • Petey Piranha • Gooper Blooper • Phantamanta • King Boo • Mecha Bowser • Eely Mouth • Wiggler|
|Minor Bosses||Polluted Piranha Plant • Plungelo • Monty Mole|
|Enemies||Enemies||Piranha Plant • Strollin' Stu • Boo/Red Boo • Bullet Bill • Electro Koopa • Snooze-a-Koopa|
|Miscellaneous||Items||Shine Sprite • 1-up Mushroom • Water Bottle • Fruit|
|Nozzles||Spray Nozzle • Hover Nozzle • Rocket Nozzle • Turbo Nozzle|
|Other||Fluff Festival • Watermelon Festival|