Crawful can be fought by Bowser and Mario and Luigi. Crawful attacks by throwing out a banana peel and slipping on it, which can be countered by a punch or a hammer depending on the character. They also attack by tripping on a rock, creating a shockwave upon landing. This can be countered by punching it, causing it to hit another enemy, if there are any, or jumping over by the bros.
At some point, the Crawful will eat a bean, which restores its health. However, if playing as Bowser, he can use his vacuum attack and suck out the Crawful's teeth, which increases his defense. If the Crawful tries to eat a bean in this phase, the bean will get stuck in its toothless gums, and fly out and offscreen, only to reappear on the other side, and hit the Crawful on the head, causing it to become dizzy.