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Mario and Luigi can fight both normal and giant bosses, instead of just normal ones like in Mario & Luigi: Bowser's Inside Story.
After winning their first battle in the Battle Ring, Mario and Luigi will receive a part of the Ultibed, which is crucial to continue the game.
- Grobot X
- Bowser and Antasma X
- Torkscrew X
- Big Massif X
- Mammoshka X
- Elite Trio X
- Pi'illodium X
- Antasma X
- Bowser Jr. (Secret Boss)